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The Intruder was equipped to carry and launch nuclear weapons B43, B57, B61 and Navy crews regularly planned for assigned nuclear missions.

Because the A-6 was a low-flying attack aircraft, a semi-automated toss bombing method was developed. Nearing the target point, the pilot would put the aircraft into a steep climb.

At a computer-calculated point in the climb, the weapon would be released, with momentum carrying it upwards and forwards. The pilot would continue the climb even more steeply, until near a vertical position the aircraft would be rolled and turned, heading back in the direction from which it came.

It would then depart from the area at maximum acceleration. During this time, the bomb would rise to an apex, still heading in its original direction, then begin to fall towards the target while traveling further forward.

At a pre-programmed height, it would detonate. By that time, the Intruder would be several miles away, traveling at top speed, and thus able to stay ahead of the shock wave from the explosion.

This unusual maneuver was known as an "over the shoulder" bomb launch. The A-6 became both the U. A-6 Intruders first saw action during the Vietnam War , where the craft were used extensively against targets in Vietnam.

However, its typical mission profile of flying low to deliver its payload made it especially vulnerable to anti-aircraft fire, and in the eight years the Intruder was used during the Vietnam War, the U.

Marine Corps lost a total of 84 A-6 aircraft of various series. An explosion under the starboard wing damaged the starboard engine, causing the aircraft to catch fire and the hydraulics to fail.

Seconds later the port engine failed, the controls froze, and the two crewmen ejected. Of the 84 Intruders lost to all causes during the war, ten were shot down by surface-to-air missiles SAMs , two were shot down by MiGs, 16 were lost to operational causes, and 56 were lost to conventional ground fire and AAA.

Graf and LT S. The airmen ejected and were rescued by a Navy helicopter. Navy aircraft carriers rotated through the waters of Southeast Asia, providing air strikes, from the early s through the early s.

Nine of those carriers lost A-6 Intruders: A-6 Intruders were later used in support of other operations, such as the Multinational Force in Lebanon in During the Gulf War in , U.

Marine Corps A-6s flew more than 4, combat sorties, providing close air support, destroying enemy air defenses, attacking Iraqi naval units, and hitting strategic targets.

They were also the U. Following the Gulf War, Intruders were used to patrol the no-fly zone in Iraq and provided air support for U.

Marines during Operation Restore Hope in Somalia. The last A-6E Intruder left U. Marine Corps service on 28 April The A-6 also saw further duty over Bosnia in The last Intruders were retired on 28 February Many in the US defense establishment in general, and Naval Aviation in particular, questioned the wisdom of a shift to a shorter range carrier-based strike force, as represented by the Hornet and Super Hornet, compared to the older generation aircraft such as the Intruder and Tomcat.

At the time of retirement, several retired A-6 airframes were awaiting rewinging at the Northrop Grumman facility at St.

Augustine Airport , Florida; these were later sunk off the coast of St. Johns County , Florida to form a fish haven named "Intruder Reef". The eight prototypes and pre-production Intruder aircraft were sometimes referred to with the YA-6A designation.

DIANE consisted of multiple radar systems: It suffered numerous teething problems, and it was several years before its reliability was established.

Hence, there is an interest in developing anti-IL-6 agents as therapy against many of these diseases. Anti-IL-6 therapy was initially developed for treatment of autoimmune diseases , but due to the role of IL-6 in chronic inflammation, IL-6 blockade was also evaluated for cancer treatment.

High IL-6 levels are associated with the development of encephalitis in children and immunodeficient mouse models infected with Enterovirus 71 ; this highly contagious virus normally causes a milder illness called Hand, foot, and mouth disease but can cause life-threatening encephalitis in some cases.

EV71 patients with a certain gene polymorphism in IL-6 also appear to be more susceptible to developing encephalitis.

IL-6 has been shown to lead to several neurological diseases through its impact on epigenetic modification within the brain.

The induction of epigenetic modification by IL-6 has been proposed as a mechanism in the pathology of schizophrenia through the hypermethylation and repression of the GAD67 promoter.

The epigenetic effects IL-6 have also been implicated in the pathology of depression. Depression is marked by altered connectivity, in particular between the anterior cingulate cortex and several other limbic areas, such as the hippocampus.

Additional preclinical and clinical data, suggest that Substance P [SP] and IL-6 may act in concert to promote major depression.

SP, a hybrid neurotransmitter-cytokine, is co-transmitted with BDNF through paleo-spinothalamic circuitry from the periphery with collaterals into key areas of the limbic system.

SP and IL6 both relax tight junctions of the blood brain barrier, such that effects seen in fMRI experiments with these molecules may be a bidirectional mix of neuronal, glial, capillary, synaptic, paracrine, or endocrine-like effects.

The IL-6 antibody sirukumab is now undergoing clinical trials against major depressive disorder. Obesity is a known risk factor in the development of severe asthma.

Recent data suggests that the inflammation associated with obesity, potentially mediated by the cytokine IL6, plays a role in causing poor lung function and increased risk for developing asthma exacerbations.

From Wikipedia, the free encyclopedia. IL6 Gene location Human Chr. Chromosome 7 human [1]. Exercise and Sport Sciences Reviews.

Journal of Applied Physiology. Compr Physiol 3 3: The Journal of Physiology. Claus Brandt and Bente K. Journal of Biomedicine and Biotechnology.

Volume , Article ID , 6 pages. Muscle as an endocrine organ: Focus on muscle-derived interleukin The Journal of Biological Chemistry. The interleukin-6 receptor can serve as an alpha-receptor for CTNF".

Expert Opinion on Investigational Drugs. Polski Merkuriusz Lekarski in Polish. Current Opinion in Rheumatology. Expert Opinion on Therapeutic Targets.

Annals of the Rheumatic Diseases. International Journal of Molecular Sciences. Do women clean the house more often than men?

Alice and Neil discuss the topic and teach you a tidy amount of vocabulary. Is food labelling clear enough to help us make healthy choices? Alice and Neil discuss chocolate chip muffins along with some other tasty vocabulary.

Who were the Muses and how did they help the creative process? Neil and Alice discuss how to be more creative. Alice and Neil make some educated guesses!

Why do some weeks just fly by but sometimes minutes can seem like hours? Neil and Alice discuss our perception of time. What will the cities of the future look like, and will we enjoy living in them?

Why is the disease diabetes on the rise? Alice and Neil talk about the role that diet has to play in this global health problem.

Why do we like to impersonate people? Neil tries out his best impression of Elvis while teaching you some related vocabulary. Does sleeping with a book under your pillow help?

Why do people often say one thing and do another? Alice and Rob ask how far hypocrisy is actually part of who we are. Do you have what it takes to go to space?

Alice and Rob discuss the challenges of a job thousands of people are keen on. Do you believe men walked on the Moon? Alice and Rob discuss why some people are suspicious about everything.

Alice and Rob discuss why we give objects emotional value. Are you a teetotaler or a drinker? Rob and Alice discuss what risk to your health regular drinking may have.

What does it take to impress the ladies in the 21st century? Neil and Alice discuss knights in shining armour. Is retirement the end of everything or just a door for new opportunities?

Alice and Rob talk about aging. Do you always agree with what most people in your group say? Neil and Sophie discuss staff meetings.

Neil and Sophie discuss the health benefits of being able to speak two languages fluently. How often do you check your phone? Neil and Sophie discuss how social media is changing the way we interact.

Sophie and Neil discover that soil has some surprising qualities and discuss how growing food can be therapeutic too. Sophie and Neil talk about traditional fairy tales for the adult market and teach you some magical vocabulary.

Neil and Sophie discuss the growing industry of team building — from zombie bootcamps to horse training for executives.

Neil and Sophie talk about gene editing, designer babies and how many errors Neil might have in his genetic code. How generous are you?

Neil and Sophie discuss Mark Zuckerberg and what it takes to be a modern-day philanthropist. Are the days of paying by cash for a latte or a newspaper nearly gone?

Tea comes in different forms — milky, sweet or spicy. Alice and Neil discuss how this Asian leaf conquered the world.

Hundreds of millions of us make the same journey day in day out. Take a hike with Alice and Neil and learn new vocabulary. Are food allergies on the increase and if so, why?

Neil and Alice talk about the growing fear of food and teach new words. Are artificial lights and late night TV ruining our sleep?

Neil and Alice discuss the issue and teach you related vocabulary. What does it take to be a good interviewer? Neil and Alice discuss TV chat show hosts and teach you some related vocabulary.

How much does appearance really matter? Neil and Alice discuss how some charities are helping those in need. Alice and Finn talk about the passion some people have for danger and the unseen threats we face every day.

Alice and Neil discuss the psychological pressures of going to university. They also teach some related vocabulary. Neil and Alice discuss the long-lasting appeal of this man with a bow and how he has changed over the centuries.

Do you know how much your partner earns? Is he or she in debt? Would this make you love them less? Should we all pay for supermarket plastic bags?

Neil and Alice take a look at the environmental impact of plastic and teach you some related words. The bicycle is the most popular form of two-wheeled transport in the world, but could we all soon be using hoverboards?

If you are sitting at a desk or answering the phone, stop for a moment and ask: Neil and Finn discuss the future of our jobs. Neil and Alice discuss what kind of book people like to be seen reading.

Do you like to impress people with a classic book in your hands? Do you dress formally or casually? Do you choose trendy items or old comfortable ones?

Rob and Will talk about the meaning of clothes. What an awful sound - cracking your knuckles! Was Charles Darwin the only man with ideas about evolution?

Rob and Neil talk about someone else who discovered it first. What are the modern day dilemmas in using a lift?

Rob and Neil discuss the awkwardness and irritation of being in one. Should young people be made to vote in elections or should we choose?

We discuss the ideas behind compulsory voting. What do we need our chins for? Rob and Neil discuss how we got them and what our chins say about us.

Listen to Neil and Rob discussing mood swings, risk taking, and why people make fun of teenagers, while they also explore some related vocabulary.

How can remote parts of the world get access to the internet? Neil and Catherine discuss a new idea for spreading knowledge.

A London apartment block has front and back entrances for private and social housing - or so-called rich and poor doors. Does it make sense to you?

Listen to a discussion whilst learning some housing-related vocabulary. Fifty years ago, on 18 March , Soviet astronaut Alexei Leonov took the first space walk.

Listen to Rob and Neil describing the struggles of that ground-breaking space mission whilst explaining some related vocabulary.

Furniture with built-in wireless charging technology - like a coffee table is now being sold. So you just pop your phone on the table, and technology does the rest!

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